> ## Documentation Index
> Fetch the complete documentation index at: https://proto.evodesign.org/docs/llms.txt
> Use this file to discover all available pages before exploring further.

# Mutation

> Mutation generators introduce point changes to an existing sequence, suited to local search around a starting point.

Mutation generators introduce point changes to an existing sequence, suited to local search around a starting point.

<div class="tool-catalog-grid">
  <a href="/docs/language/generators/esm2" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/generator/esm2/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/generators/esm3" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/generator/esm3/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/generators/freebindcraft" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/generator/freebindcraft/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/generators/mpnn-mutation" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/generator/mpnn-mutation/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/generators/msa" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/generator/msa/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/generators/random-nucleotide" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/generator/random-nucleotide/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/generators/random-protein" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/generator/random-protein/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/generators/rfdiffusion-mpnn-binder" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/generator/rfdiffusion-mpnn-binder/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/generators/semigreedy-mutation" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/generator/semigreedy-mutation/carousel.png" alt="" loading="lazy" />
  </a>
</div>