> ## Documentation Index
> Fetch the complete documentation index at: https://proto.evodesign.org/docs/llms.txt
> Use this file to discover all available pages before exploring further.

# Causal Models

> Autoregressive models for sequence generation and scoring

Autoregressive language models for biological sequences. Trained to predict the next residue
or nucleotide from the sequence so far, they generate new sequences one token at a time from
an optional prompt and score how likely an existing sequence is under the model. That
likelihood serves as a zero-shot proxy for how natural a sequence looks, across both DNA and
protein alphabets.

* **Input:** a sequence to score, or a prompt to extend (DNA or protein).
* **Output:** newly generated sequences, or per-sequence likelihood and perplexity scores.

<div class="tool-catalog-grid">
  <a href="/docs/tools/causal-models/evo1" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/tool/evo1/carousel.png" alt="" loading="lazy" />

    <div class="tool-card-org-row"><span class="tool-card-org tool-card-org-light" style={{background: "#e0e0e0"}} title="Arc Institute"><img src="https://mintcdn.com/bio-pro/_UGa2jUMKeVPCbLk/assets/images/cached/2f286ca379a2.png?fit=max&auto=format&n=_UGa2jUMKeVPCbLk&q=85&s=8dfa2f559c96e84c86ef4d3df3cb39d7" alt="" class="tool-card-org-logo" width="200" height="200" data-path="assets/images/cached/2f286ca379a2.png" /> Arc Institute</span></div>
  </a>

  <a href="/docs/tools/causal-models/evo2" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/tool/evo2/carousel.png" alt="" loading="lazy" />

    <div class="tool-card-org-row"><span class="tool-card-org tool-card-org-light" style={{background: "#e0e0e0"}} title="Arc Institute"><img src="https://mintcdn.com/bio-pro/_UGa2jUMKeVPCbLk/assets/images/cached/2f286ca379a2.png?fit=max&auto=format&n=_UGa2jUMKeVPCbLk&q=85&s=8dfa2f559c96e84c86ef4d3df3cb39d7" alt="" class="tool-card-org-logo" width="200" height="200" data-path="assets/images/cached/2f286ca379a2.png" /> Arc Institute</span></div>
  </a>

  <a href="/docs/tools/causal-models/progen2" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/tool/progen2/carousel.png" alt="" loading="lazy" />

    <div class="tool-card-org-row"><span class="tool-card-org" style={{background: "#00A1E0"}} title="Salesforce Research"><img src="https://mintcdn.com/bio-pro/_UGa2jUMKeVPCbLk/assets/images/cached/8968678dd27c.png?fit=max&auto=format&n=_UGa2jUMKeVPCbLk&q=85&s=90ccf0cdbec4208b08905f5e12d0ebd6" alt="" class="tool-card-org-logo" width="187" height="187" data-path="assets/images/cached/8968678dd27c.png" /> Salesforce Research</span></div>
  </a>

  <a href="/docs/tools/causal-models/progen3" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/tool/progen3/carousel.png" alt="" loading="lazy" />

    <div class="tool-card-org-row"><span class="tool-card-org" style={{background: "#2A9D8F"}} title="Profluent"><img src="https://mintcdn.com/bio-pro/_UGa2jUMKeVPCbLk/assets/images/cached/e4f184a1b145.png?fit=max&auto=format&n=_UGa2jUMKeVPCbLk&q=85&s=c04d16dc65a95665e453a13a8684438a" alt="" class="tool-card-org-logo" width="200" height="200" data-path="assets/images/cached/e4f184a1b145.png" /> Profluent</span></div>
  </a>
</div>
