> ## Documentation Index > Fetch the complete documentation index at: https://proto.evodesign.org/docs/llms.txt > Use this file to discover all available pages before exploring further. # Inverse Folding > Design sequences that fold into target structures Design amino acid sequences predicted to fold into a given three-dimensional backbone. These tools solve the inverse of structure prediction: given a target structure, they propose sequences that should adopt it, and score how compatible a sequence is with a backbone. Design can be conditioned on fixed positions and on any bound ligands, metals, or nucleic acids. * **Input:** a target 3D backbone, optionally with fixed positions or bound ligands, metals, and nucleic acids to respect. * **Output:** one or more sequences predicted to fold into that backbone, each with a compatibility (likelihood) score.

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