> ## Documentation Index
> Fetch the complete documentation index at: https://proto.evodesign.org/docs/llms.txt
> Use this file to discover all available pages before exploring further.

# ORF Prediction

> Find open reading frames and genes in DNA sequences

Identify open reading frames and predict protein-coding genes in DNA sequences. These tools
locate candidate coding regions across reading frames and strands and translate them to
protein, ranging from simple codon-based scanning to statistical gene finding for
prokaryotic genomes.

* **Input:** one or more DNA sequences.
* **Output:** the predicted open reading frames (coordinates, strand, and frame) and their translated protein sequences.

<div class="tool-catalog-grid">
  <a href="/docs/tools/orf-prediction/orfipy" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/tool/orfipy/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/tools/orf-prediction/prodigal" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/tool/prodigal/carousel.png" alt="" loading="lazy" />
  </a>
</div>