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De novo nanobody design
Example · Read-only
Optimization Stages
Design candidates
1
Select optimizer
2
Select optimizer
3
Select optimizer
Program Graph
VHH binder scaffold
VHH binder scaffold chain
AF2 distogram CCE
AF2 PD-L1/VHH interface contacts
AF2 complex pLDDT confidence
AF2 complex PAE
AF2 radius of gyration
AF2 interface pTM
AF2 interface PAE
AF2 interface pLDDT confidence
AF2 VHH beta-strand
AF2 intrachain contacts
AF2 helix content
AbLang VHH likelihood
CDR logit-gradient designer
PD-L1 target antigen
PD-L1 extracellular-domain target
AF2 distogram CCE
AF2 PD-L1/VHH interface contacts
AF2 complex pLDDT confidence
AF2 complex PAE
AF2 radius of gyration
AF2 interface pTM
AF2 interface PAE
AF2 interface pLDDT confidence
AF2 VHH beta-strand
AF2 intrachain contacts
AF2 helix content
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VHH binder scaffold
PD-L1 target antigen
VHH binder scaffold chain
131 aa
Q
V
Q
L
V
E
S
G
G
G
L
V
Q
P
G
G
S
L
R
…
PD-L1 extracellular-domain target
Const
115 aa
A
F
T
V
T
V
P
K
D
L
Y
V
V
E
Y
G
S
N
M
…
AF2 distogram CCE
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AF2 PD-L1/VHH interface contacts
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AF2 complex pLDDT confidence
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AF2 complex PAE
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AF2 radius of gyration
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AF2 interface pTM
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AF2 interface PAE
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AF2 interface pLDDT confidence
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AF2 VHH beta-strand
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AF2 intrachain contacts
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AF2 helix content
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AbLang VHH likelihood
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CDR logit-gradient designer
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Segments
DNA
RNA
Protein
Ligand
Optimization
Constraint
Generator
Biological programming language