> ## Documentation Index
> Fetch the complete documentation index at: https://proto.evodesign.org/docs/llms.txt
> Use this file to discover all available pages before exploring further.

# Protein Structure

> Constraints grouped under Protein Structure. Each scores a sequence from 0.0 (perfectly satisfied) to 1.0 (maximally violated). Select a constraint below for its full reference and configuration.

Constraints grouped under Protein Structure. Each scores a sequence from 0.0 (perfectly satisfied) to 1.0 (maximally violated). Select a constraint below for its full reference and configuration.

<div class="tool-catalog-grid">
  <a href="/docs/language/constraints/af3-chain-pair-prot-dna-iptm" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/af3-chain-pair-prot-dna-iptm/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/af3-offtarget-iptm-specificity" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/af3-offtarget-iptm-specificity/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/boltz2-binding-strength" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/boltz2-binding-strength/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/consensus-operator-specificity" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/consensus-operator-specificity/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/dbp-design-metrics" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/dbp-design-metrics/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/deeppbs-motif-specificity" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/deeppbs-motif-specificity/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/dna-base-contact-quality" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/dna-base-contact-quality/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/dna-motif-contact-count" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/dna-motif-contact-count/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/dna-phosphate-contact" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/dna-phosphate-contact/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/gyration-radius" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/gyration-radius/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/metal3d-probability" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/metal3d-probability/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/na-mpnn-motif-specificity" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/na-mpnn-motif-specificity/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/protein-dna-ipsae" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/protein-dna-ipsae/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/protein-globularity" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/protein-globularity/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/protein-symmetry-ring" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/protein-symmetry-ring/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/pyrosetta-interface" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/pyrosetta-interface/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/structure-beta-strand" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/structure-beta-strand/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/structure-composite" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/structure-composite/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/structure-contact" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/structure-contact/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/structure-distogram-cce" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/structure-distogram-cce/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/structure-ensemble-rmsd" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/structure-ensemble-rmsd/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/structure-helix" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/structure-helix/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/structure-interface-contact" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/structure-interface-contact/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/structure-ipae" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/structure-ipae/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/structure-iplddt" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/structure-iplddt/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/structure-iptm" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/structure-iptm/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/structure-pae" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/structure-pae/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/structure-plddt" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/structure-plddt/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/structure-ptm" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/structure-ptm/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/structure-radius-gyration" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/structure-radius-gyration/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/structure-rmsd" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/structure-rmsd/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/structure-termini-distance" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/structure-termini-distance/carousel.png" alt="" loading="lazy" />
  </a>

  <a href="/docs/language/constraints/structure-tmscore" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/constraint/structure-tmscore/carousel.png" alt="" loading="lazy" />
  </a>
</div>