> ## Documentation Index > Fetch the complete documentation index at: https://proto.evodesign.org/docs/llms.txt > Use this file to discover all available pages before exploring further. # Sequence Scoring > Predict functional effects from genomic sequences Predict functional genomic readouts directly from DNA sequence, including gene expression, chromatin accessibility, transcription initiation, and regulatory activity. These tools estimate how a sequence behaves and how variants change that behavior, at resolutions ranging from individual regulatory elements to long genomic windows. * **Input:** a DNA sequence, or a sequence variant to evaluate. * **Output:** predicted functional and regulatory activity (such as expression or accessibility), or a variant's effect on it.

Calico

USC

Google DeepMind

Broad Institute

The Jackson Laboratory

Yale University

UCSF

Autosome.org

UT Southwestern

St. Jude

NCBI