> ## Documentation Index
> Fetch the complete documentation index at: https://proto.evodesign.org/docs/llms.txt
> Use this file to discover all available pages before exploring further.

# Structure Prediction

> Predict 3D protein and RNA structures from sequences

Predict three-dimensional molecular structure from sequence. These tools range from fast
single-sequence folding to co-folding models that handle protein complexes, nucleic acids,
and ligands, and most report confidence scores that indicate how reliable each part of a
prediction is.

* **Input:** one or more sequences, optionally assembled into a multi-chain complex with nucleic acids or ligands.
* **Output:** a predicted 3D structure for each input, annotated with per-residue and per-interface confidence scores.

<div class="tool-catalog-grid">
  <a href="/docs/tools/structure-prediction/alphafold2" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/tool/alphafold2/carousel.png" alt="" loading="lazy" />

    <div class="tool-card-org-row"><span class="tool-card-org" style={{background: "#1a237e"}} title="Google DeepMind"><img src="https://mintcdn.com/bio-pro/_UGa2jUMKeVPCbLk/assets/images/cached/170f4f446634.png?fit=max&auto=format&n=_UGa2jUMKeVPCbLk&q=85&s=c925c2862540b2476392ff2a71a0dba8" alt="" class="tool-card-org-logo" width="200" height="200" data-path="assets/images/cached/170f4f446634.png" /> Google DeepMind</span></div>
  </a>

  <a href="/docs/tools/structure-prediction/alphafold3" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/tool/alphafold3/carousel.png" alt="" loading="lazy" />

    <div class="tool-card-org-row"><span class="tool-card-org" style={{background: "#1a237e"}} title="Google DeepMind"><img src="https://mintcdn.com/bio-pro/_UGa2jUMKeVPCbLk/assets/images/cached/170f4f446634.png?fit=max&auto=format&n=_UGa2jUMKeVPCbLk&q=85&s=c925c2862540b2476392ff2a71a0dba8" alt="" class="tool-card-org-logo" width="200" height="200" data-path="assets/images/cached/170f4f446634.png" /> Google DeepMind</span></div>
  </a>

  <a href="/docs/tools/structure-prediction/boltz2" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/tool/boltz2/carousel.png" alt="" loading="lazy" />

    <div class="tool-card-org-row"><span class="tool-card-org" style={{background: "#1a1a2e"}} title="Boltz"><img src="https://mintcdn.com/bio-pro/UeudeF7pW-Dj-pIN/assets/images/cached/36a76d515bf7.png?fit=max&auto=format&n=UeudeF7pW-Dj-pIN&q=85&s=d73a2cce4e60e021d75b3b2caf2e92d9" alt="" class="tool-card-org-logo" width="512" height="512" data-path="assets/images/cached/36a76d515bf7.png" /> Boltz</span> <span class="tool-card-org" style={{background: "#A31F34"}} title="MIT Jameel Clinic"><img src="https://mintcdn.com/bio-pro/UeudeF7pW-Dj-pIN/assets/images/cached/1b19a19f88c7.png?fit=max&auto=format&n=UeudeF7pW-Dj-pIN&q=85&s=10230467db9fb147674aea6cebc5968a" alt="" class="tool-card-org-logo" width="32" height="32" data-path="assets/images/cached/1b19a19f88c7.png" /> MIT Jameel Clinic</span> <span class="tool-card-org" style={{background: "#0B0B45"}} title="Recursion"><img src="https://mintcdn.com/bio-pro/UeudeF7pW-Dj-pIN/assets/images/cached/732f1fb1b8c3.png?fit=max&auto=format&n=UeudeF7pW-Dj-pIN&q=85&s=180aa78503d58078e12516e00f3c629a" alt="" class="tool-card-org-logo" width="132" height="132" data-path="assets/images/cached/732f1fb1b8c3.png" /> Recursion</span></div>
  </a>

  <a href="/docs/tools/structure-prediction/chai1" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/tool/chai1/carousel.png" alt="" loading="lazy" />

    <div class="tool-card-org-row"><span class="tool-card-org" style={{background: "#2A2D3E"}} title="Chai Discovery"><img src="https://mintcdn.com/bio-pro/_UGa2jUMKeVPCbLk/assets/images/cached/5182c572b1a6.png?fit=max&auto=format&n=_UGa2jUMKeVPCbLk&q=85&s=efb52734bb4f3d788f83f73eb9f73e89" alt="" class="tool-card-org-logo" width="128" height="128" data-path="assets/images/cached/5182c572b1a6.png" /> Chai Discovery</span></div>
  </a>

  <a href="/docs/tools/structure-prediction/esmfold" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/tool/esmfold/carousel.png" alt="" loading="lazy" />

    <div class="tool-card-org-row"><span class="tool-card-org" style={{background: "#0866FF"}} title="Meta AI"><img src="https://mintcdn.com/bio-pro/_UGa2jUMKeVPCbLk/assets/images/cached/122d88bc7259.png?fit=max&auto=format&n=_UGa2jUMKeVPCbLk&q=85&s=ca6fedad598bccf781a70ad3b02bf561" alt="" class="tool-card-org-logo" width="200" height="200" data-path="assets/images/cached/122d88bc7259.png" /> Meta AI</span></div>
  </a>

  <a href="/docs/tools/structure-prediction/esmfold2" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/tool/esmfold2/carousel.png" alt="" loading="lazy" />

    <div class="tool-card-org-row"><span class="tool-card-org" style={{background: "#111111"}} title="Biohub"><img src="https://mintcdn.com/bio-pro/_UGa2jUMKeVPCbLk/assets/images/cached/59f8c7606fb7.png?fit=max&auto=format&n=_UGa2jUMKeVPCbLk&q=85&s=e4891edc150dd75c0f1e262cfdb2d304" alt="" class="tool-card-org-logo" width="192" height="192" data-path="assets/images/cached/59f8c7606fb7.png" /> Biohub</span></div>
  </a>

  <a href="/docs/tools/structure-prediction/opendde" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/tool/opendde/carousel.png" alt="" loading="lazy" />

    <div class="tool-card-org-row"><span class="tool-card-org" style={{background: "#4B42E5"}} title="Aureka AI Research"><img src="https://mintcdn.com/bio-pro/LOWQrNBaTrwTO8Yk/assets/images/org-logos/aureka-ai-research.svg?fit=max&auto=format&n=LOWQrNBaTrwTO8Yk&q=85&s=1e7fcd94844e91aee35fc1e32e5c99ea" alt="" class="tool-card-org-logo" width="64" height="64" data-path="assets/images/org-logos/aureka-ai-research.svg" /> Aureka AI Research</span></div>
  </a>

  <a href="/docs/tools/structure-prediction/protenix" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/tool/protenix/carousel.png" alt="" loading="lazy" />

    <div class="tool-card-org-row"><span class="tool-card-org" style={{background: "#046e7a"}} title="ByteDance"><img src="https://mintcdn.com/bio-pro/_UGa2jUMKeVPCbLk/assets/images/cached/3cdb88d78ac3.png?fit=max&auto=format&n=_UGa2jUMKeVPCbLk&q=85&s=88d205174e21cf58ec4f6a266956baf9" alt="" class="tool-card-org-logo" width="200" height="200" data-path="assets/images/cached/3cdb88d78ac3.png" /> ByteDance</span></div>
  </a>

  <a href="/docs/tools/structure-prediction/rf3" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/tool/rf3/carousel.png" alt="" loading="lazy" />

    <div class="tool-card-org-row"><span class="tool-card-org" style={{background: "#4b2e83"}} title="Institute for Protein Design"><img src="https://mintcdn.com/bio-pro/_UGa2jUMKeVPCbLk/assets/images/cached/6c4da2f317fc.png?fit=max&auto=format&n=_UGa2jUMKeVPCbLk&q=85&s=e0eec78648cb6cc4938f40ab18608b31" alt="" class="tool-card-org-logo" width="200" height="200" data-path="assets/images/cached/6c4da2f317fc.png" /> IPD</span></div>
  </a>

  <a href="/docs/tools/structure-prediction/viennarna" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/tool/viennarna/carousel.png" alt="" loading="lazy" />

    <div class="tool-card-org-row"><span class="tool-card-org" style={{background: "#8b1a1a"}} title="TBI Vienna"><img src="https://mintcdn.com/bio-pro/_UGa2jUMKeVPCbLk/assets/images/cached/a11d21d46ba0.png?fit=max&auto=format&n=_UGa2jUMKeVPCbLk&q=85&s=c5402b84892190e419a4f415a5e48eef" alt="" class="tool-card-org-logo" width="200" height="200" data-path="assets/images/cached/a11d21d46ba0.png" /> TBI Vienna</span></div>
  </a>

  <a href="/docs/tools/structure-prediction/x3dna" class="tool-catalog-card">
    <img noZoom class="card-art" src="https://proto-bio.github.io/proto-assets/images/tool/x3dna/carousel.png" alt="" loading="lazy" />

    <div class="tool-card-org-row"><span class="tool-card-org" style={{background: "#CC0033"}} title="Rutgers University"><img src="https://mintcdn.com/bio-pro/rW-ZVHoYhZw2v7T_/assets/images/cached/62fac4ff4e57.png?fit=max&auto=format&n=rW-ZVHoYhZw2v7T_&q=85&s=4a9afe4808054f2bbef99b3a0d27a2e4" alt="" class="tool-card-org-logo" width="330" height="331" data-path="assets/images/cached/62fac4ff4e57.png" /> Rutgers University</span> <span class="tool-card-org" style={{background: "#1D4F91"}} title="Columbia University"><img src="https://mintcdn.com/bio-pro/rW-ZVHoYhZw2v7T_/assets/images/cached/d5d148878514.png?fit=max&auto=format&n=rW-ZVHoYhZw2v7T_&q=85&s=9f7713e2715ee28f46c31860e87f1d0a" alt="" class="tool-card-org-logo" width="330" height="431" data-path="assets/images/cached/d5d148878514.png" /> Columbia University</span></div>
  </a>
</div>
